Int J Biochem Mol Biol 2011;2(1):89-98
Original Article
Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers
Youyun Yang, Hailan Liu, Zhaomin Li, Zijin Zhao, Michelle Yip-Schneider, Qipeng Fan, C. Max Schmidt, E. Gabriela Chiorean, Jingwu Xie, Liang
Cheng, Jey-Hsin Chen, Jian-Ting Zhang
Department of Pharmacology and Toxicology, Department of Pathology and Laboratory Medicine, Department of Surgery, Department of
Pediatrics, Department of Medicine, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Received January 28, 2011; accepted January 30, 2011; Epub January 31, 2011; Published February 15, 2011
Abstract: Human fatty acid synthase (FASN) is a homo-dimeric protein with multi-enzymatic activity responsible for the synthesis of palmitate.
FASN expression has been found to be up-regulated in multiple types of human cancers and its expression correlates with poor prognosis
possibly by causing treatment resistance. In this study, we tested if FASN expression is up-regulated in human pancreatic cancers and if its
higher expression level in pancreatic cancers causes intrinsic resistance to gemcitabine and radiation. We found that FASN expression is
significantly up-regulated in human pancreatic cancer tissues without any correlation to age, sex, race, and tumor stage. Knocking down or
over-expressing FASN significantly down- or up-regulate resistance of pancreatic cancer cell lines to both gemcitabine and radiation
treatments. These findings imply that the elevated FASN expression in pancreatic cancers may contribute to unsuccessful treatments of
pancreatic cancers by causing intrinsic resistance to both chemotherapy and radiation therapy. (IJBMB1011004).
Keywords: Human fatty acid synthase (FASN), palmitate, gemcitabine, radiation treatments, treatment resistance,
pancreatic cancers
Full Text PDF
Address all correspondence to:
Dr. Jian-Ting Zhang
Andrew and Peggy Thomson Chair in Hematology/Oncology
Department of Pharmacology & Toxicology
Indiana University School of Medicine
980 W. Walnut Street, R3-C510, Indianapolis, IN 46202, USA.
Tel. (317) 278-4503, Fax (317) 274-8046
E-mail: jianzhan@exchange.iu.edu
Original Article
Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers
Youyun Yang, Hailan Liu, Zhaomin Li, Zijin Zhao, Michelle Yip-Schneider, Qipeng Fan, C. Max Schmidt, E. Gabriela Chiorean, Jingwu Xie, Liang
Cheng, Jey-Hsin Chen, Jian-Ting Zhang
Department of Pharmacology and Toxicology, Department of Pathology and Laboratory Medicine, Department of Surgery, Department of
Pediatrics, Department of Medicine, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Received January 28, 2011; accepted January 30, 2011; Epub January 31, 2011; Published February 15, 2011
Abstract: Human fatty acid synthase (FASN) is a homo-dimeric protein with multi-enzymatic activity responsible for the synthesis of palmitate.
FASN expression has been found to be up-regulated in multiple types of human cancers and its expression correlates with poor prognosis
possibly by causing treatment resistance. In this study, we tested if FASN expression is up-regulated in human pancreatic cancers and if its
higher expression level in pancreatic cancers causes intrinsic resistance to gemcitabine and radiation. We found that FASN expression is
significantly up-regulated in human pancreatic cancer tissues without any correlation to age, sex, race, and tumor stage. Knocking down or
over-expressing FASN significantly down- or up-regulate resistance of pancreatic cancer cell lines to both gemcitabine and radiation
treatments. These findings imply that the elevated FASN expression in pancreatic cancers may contribute to unsuccessful treatments of
pancreatic cancers by causing intrinsic resistance to both chemotherapy and radiation therapy. (IJBMB1011004).
Keywords: Human fatty acid synthase (FASN), palmitate, gemcitabine, radiation treatments, treatment resistance,
pancreatic cancers
Full Text PDF
Address all correspondence to:
Dr. Jian-Ting Zhang
Andrew and Peggy Thomson Chair in Hematology/Oncology
Department of Pharmacology & Toxicology
Indiana University School of Medicine
980 W. Walnut Street, R3-C510, Indianapolis, IN 46202, USA.
Tel. (317) 278-4503, Fax (317) 274-8046
E-mail: jianzhan@exchange.iu.edu
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