Int J Biochem Mol Biol 2011;2(3):228-239

Review Article
What we have learnt about PIKE from the knockout mice

Chi Bun Chan, Keqiang Ye

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA

Received May 12, 2011; accepted May 28, 2011; Epub June 7, 2011; Published August 30, 2011

Abstract: Phosphoinositide 3-kinase enhancer (PIKE) is a group of GTPase that belongs to the Centaurin superfamily. These proteins were
discovered for about a decade ago, but our understandings regarding their functions are still limited. Studies from our group and others have
revealed some of their functions in a cellular context, but their roles in organ development or systemic homeostasis just begin to unveil. The
generation of PIKE knockout mice thus provides the valuable model to delineate the physiological roles of PIKE. In addition to being a PI3K/Akt
enhancer, phenotypic characterization of PIKE knockout mice demonstrates that the proteins are involved in multiple signaling cascades
including Janus kinase (JAK)/ Signal Transducer and Activator of Transcription (STAT), AMP-activated protein kinase (AMPK)/Acetyl-CoA
carboxylase (ACC) and insulin receptor (IR)/Akt. In this article, we will review the current findings from the PIKE knockout mice studies and will
discuss how these in vivo observations lead to the identification of novel signaling cascades regulated by PIKE. (IJBMB1105001).

Keywords: Adipocyte, BDNF, GluR2, insulin receptor, liver, mammary, neuron, obesity, PIKE

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Address all correspondence to:
Keqiang Ye, PhD
Department of Pathology and Laboratory Medicine
Emory University School of Medicine
615 Michael Street
Atlanta, GA 30322, USA.
Tel: 404-712-2814; Fax: 404-712-2979