Int J Biochem Mol Biol 2011;2(3):240-246

Review Article
Cellular and molecular effects of thiazolidinediones on bone cells: a review

Guillaume Mabilleau, Daniel Chappard, Michel F. Baslé

INSERM, U922-LHEA, University of Angers, Angers, France; SCIAM, University of Angers, Angers, France

Received May 30, 2011; accepted June 18, 2011; Epub June 20, 2011; Published August 30, 2011

Abstract: Thiazolidinediones represent a class of molecules used in the treatment of type 2 diabetes mellitus. Despite interesting effects in
lowering blood glucose and HbA1c levels durably, an augmentation of the fracture risk in women has emerged in the past years. This review is
providing the readers with information about the cellular and molecular mechanisms involved in bone and bone cells in response to these
drugs. (IJBMB1105003).

Keywords: Thiazolidinediones, osteoclast, osteoblast, osteocyte, PPARg, diabetes mellitus

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Address all correspondence to:
Dr. Guillaume Mabilleau
IINSERM U922 “Bone remodeling and Biomaterials”
Institut de Biologie en Santé, CHU d’Angers
4 Rue Larrey, 49933 Angers cedex 09, France
Tel: 332 44 68 84 55 Fax: +332 44 68 84 51