Int J Biochem Mol Biol 2011;2(3):247-256
Regulation and function of the TAZ transcription co-activator
Chenying Liu, Wei Huang, Qunying Lei
Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College;
Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Received June 24, 2011; accepted JUly 11, 2011; Epub July 20, 2011; Published August 30, 2011
Abstract: TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif, is implicated in mesenchymal stem cell differentiation.
TAZ has been shown to be negatively regulated by phosphorylation–dependent and phosphorylation-independent mechanism. Coupled with
ASPP2, PP1 dephosphorylates TAZ to activate TAZ. TEADs mediate TAZ function in promoting cell proliferation and epithelial-mesenchymal
transition (EMT). TAZ senses different cellular signals such as cell density and the extracellular matrix stiffness. Significantly, TAZ is
overexpressed in breast cancer samples and papillary thyroid carcinoma tissues. These results indicate that TAZ plays an important role in
cancer development and presents a novel target for TAZ overexpressed cancer therapy. (IJBMB1106001).
Keywords: TAZ (WWTR1), 14-3-3 binding protein, PDZ binding motif, stem cell, epithelial-mesenchymal transition (EMT), signal transduction
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Address all correspondence to:
Dr. Qunying Lei
Molecular and Cell Biology Lab
Institutes of Biomedical Sciences
Fudan University, Shanghai 200032, China.