Int J Biochem Mol Biol 2011;2(3):257-262

Review Article
Mitochondria and antiviral innate immunity

Takumi Koshiba, Nasir Bashiruddin, Shunichiro Kawabata

Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.

Received July 28, 2011; accepted August 9, 2011; Epub August 16, 2011; Published August 30, 2011

Abstract: Mitochondria, dynamic organelles that undergo continuous cycles of fusion and fission, are the powerhouses of eukaryotic cells.
Recent research indicates that mitochondria also act as platforms for antiviral immunity in vertebrates. Mitochondrial-mediated antiviral
immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and the participation of
the mitochondrial outer membrane adaptor protein “mitochondrial antiviral signaling (MAVS)”. Here we discuss recent findings that suggest
how mitochondria contribute to antiviral innate immunity.(IJBMB1105003).

Keywords: Mitochondrion, antiviral innate immunity, MAVS, RLRs pathway, signal transduction, mitochondrial dynamics

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Address all correspondence to:
Dr. Takumi Koshiba
Department of Biology, Faculty of Sciences
Kyushu University, 6-10-1 Hakozaki, Higashi-ku
Fukuoka 812-8581, Japan.
Tel: +81 92 642-2633
Fax: +81 92 642-2633;
E-mail: koshiba@kyudai.jp
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