Int J Biochem Mol Biol 2012;3(2):165-178
Review Article
Targeted genes and interacting proteins of hypoxia inducible factor-1
Wei Liu, Shao-Ming Shen, Xu-Yun Zhao, Guo-Qiang Chen
Department of Pathophysiology, Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of
Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, CHINA; Institute of Health
Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences & SJTU-SM, Shanghai 200025, CHINA
Received March 5, 2012; accepted May 3, 2012; Epub May 31, 2012; Published June 15, 2012
Abstract: Heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1) functions as a master regulator of oxygen homeostasis in almost
all nucleated mammalian cells. The fundamental process adapted to cellular oxygen alteration largely depends on the refined regulation on its
alpha subunit, HIF-1α. Recent studies have unraveled expanding and critical roles of HIF-1α, involving in a multitude of developmental,
physiological, and pathophysiological processes. This review will focus on the current knowledge of HIF-1α-targeting genes and its interacting
proteins, as well as the concomitant functional relationships between them. (IJBMB1203001)
Keywords: Hypoxia inducible factor-1alpha, targeting gene, interacting protein
Address all correspondence to:
Dr. Guo-Qiang Chen, Department of Pathophysiology, Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell
Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai
200025, CHINA; Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences & SJTU-SM,
Shanghai 200025, CHINA E-mail: chengq@shsmu.edu.cn or gqchen@sibs.ac.cn
Review Article
Targeted genes and interacting proteins of hypoxia inducible factor-1
Wei Liu, Shao-Ming Shen, Xu-Yun Zhao, Guo-Qiang Chen
Department of Pathophysiology, Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of
Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, CHINA; Institute of Health
Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences & SJTU-SM, Shanghai 200025, CHINA
Received March 5, 2012; accepted May 3, 2012; Epub May 31, 2012; Published June 15, 2012
Abstract: Heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1) functions as a master regulator of oxygen homeostasis in almost
all nucleated mammalian cells. The fundamental process adapted to cellular oxygen alteration largely depends on the refined regulation on its
alpha subunit, HIF-1α. Recent studies have unraveled expanding and critical roles of HIF-1α, involving in a multitude of developmental,
physiological, and pathophysiological processes. This review will focus on the current knowledge of HIF-1α-targeting genes and its interacting
proteins, as well as the concomitant functional relationships between them. (IJBMB1203001)
Keywords: Hypoxia inducible factor-1alpha, targeting gene, interacting protein
Address all correspondence to:
Dr. Guo-Qiang Chen, Department of Pathophysiology, Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell
Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai
200025, CHINA; Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences & SJTU-SM,
Shanghai 200025, CHINA E-mail: chengq@shsmu.edu.cn or gqchen@sibs.ac.cn
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