Int J Biochem Mol Biol 2012;3(2):152-164
Review Article
14-3-3 proteins in neurological disorders
Molly Foote, Yi Zhou
Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA
Received March 14, 2012; accepted April 28, 2012; Epub May 18, 2012; Published June 15, 2012
Abstract: 14-3-3 proteins were originally discovered as a family of proteins that are highly expressed in the brain. Through interactions with a
multitude of binding partners, 14-3-3 proteins impact many aspects of brain function including neural signaling, neuronal development and
neuroprotection. Although much remains to be learned and understood, 14-3-3 proteins have been implicated in a variety of neurological
disorders based on evidence from both clinical and laboratory studies. Here we will review previous and more recent research that has helped
us understand the roles of 14-3-3 proteins in both neurodegenerative and neuropsychiatric diseases. (IJBMB1203004)
Keywords: 14-3-3, neurodegenerative diseases, neurodevelopment, neuropsychiatric diseases
Address all correspondence to:
Dr. Yi Zhou
1115 West Call Street
Florida State University
Tallahassee, FL 32306, USA.
Tel: (850) 645-8217; Fax: (850) 644-5781
E-mail: yzhou@fsu.edu
Review Article
14-3-3 proteins in neurological disorders
Molly Foote, Yi Zhou
Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA
Received March 14, 2012; accepted April 28, 2012; Epub May 18, 2012; Published June 15, 2012
Abstract: 14-3-3 proteins were originally discovered as a family of proteins that are highly expressed in the brain. Through interactions with a
multitude of binding partners, 14-3-3 proteins impact many aspects of brain function including neural signaling, neuronal development and
neuroprotection. Although much remains to be learned and understood, 14-3-3 proteins have been implicated in a variety of neurological
disorders based on evidence from both clinical and laboratory studies. Here we will review previous and more recent research that has helped
us understand the roles of 14-3-3 proteins in both neurodegenerative and neuropsychiatric diseases. (IJBMB1203004)
Keywords: 14-3-3, neurodegenerative diseases, neurodevelopment, neuropsychiatric diseases
Address all correspondence to:
Dr. Yi Zhou
1115 West Call Street
Florida State University
Tallahassee, FL 32306, USA.
Tel: (850) 645-8217; Fax: (850) 644-5781
E-mail: yzhou@fsu.edu
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