Int J Biochem Mol Biol 2012;3(2):198-208
Review Article
BAR proteins in cancer and blood disorders
Yolande Chen, Jorie Aardema, Ashish Misra, Seth J Corey
Departments of Pediatrics and Cell & Molecular Biology, Children’s Memorial Hospital, Robert H. Lurie Comprehensive Cancer Center,
Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Cardiology, Department of Medicine, Yale University School of
Medicine, New Haven, CT, USA.
Received April 13, 2012; accepted April 18, 2012; Epub May 18, 2012; Published June 15, 2012
Abstract: Remodeling of the membrane and cytoskeleton is involved in a wide range of normal and pathologic cellular function. These are
complex, highly-coordinated biochemical and biophysical processes involving dozens of proteins. Serving as a scaffold for a variety of proteins
and possessing a domain that interacts with plasma membranes, the BAR family of proteins contribute to a range of cellular functions
characterized by membrane and cytoskeletal remodeling. There are several subgroups of BAR proteins: BAR, N-BAR, I-BAR, and F-BAR. They
differ in their ability to induce angles of membrane curvature and in their recruitment of effector proteins. Evidence is accumulating that BAR
proteins contribute to cancer cell invasion, T cell trafficking, phagocytosis, and platelet production. In this review, we discuss the physiological
function of BAR proteins and discuss how they contribute to blood and cancer disorders. (IJBMB1204003)
Keywords: BAR proteins, GTPases, WASP, blood, cancer
Address all correspondence to:
Dr. Seth J Corey
303 E. Superior Street
Lurie 5-107, Chicago, IL 60611, USA.
Tel: 312-503-6694; Fax: 312-503-0189
E-mail: s-corey@northwestern.edu
Review Article
BAR proteins in cancer and blood disorders
Yolande Chen, Jorie Aardema, Ashish Misra, Seth J Corey
Departments of Pediatrics and Cell & Molecular Biology, Children’s Memorial Hospital, Robert H. Lurie Comprehensive Cancer Center,
Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Cardiology, Department of Medicine, Yale University School of
Medicine, New Haven, CT, USA.
Received April 13, 2012; accepted April 18, 2012; Epub May 18, 2012; Published June 15, 2012
Abstract: Remodeling of the membrane and cytoskeleton is involved in a wide range of normal and pathologic cellular function. These are
complex, highly-coordinated biochemical and biophysical processes involving dozens of proteins. Serving as a scaffold for a variety of proteins
and possessing a domain that interacts with plasma membranes, the BAR family of proteins contribute to a range of cellular functions
characterized by membrane and cytoskeletal remodeling. There are several subgroups of BAR proteins: BAR, N-BAR, I-BAR, and F-BAR. They
differ in their ability to induce angles of membrane curvature and in their recruitment of effector proteins. Evidence is accumulating that BAR
proteins contribute to cancer cell invasion, T cell trafficking, phagocytosis, and platelet production. In this review, we discuss the physiological
function of BAR proteins and discuss how they contribute to blood and cancer disorders. (IJBMB1204003)
Keywords: BAR proteins, GTPases, WASP, blood, cancer
Address all correspondence to:
Dr. Seth J Corey
303 E. Superior Street
Lurie 5-107, Chicago, IL 60611, USA.
Tel: 312-503-6694; Fax: 312-503-0189
E-mail: s-corey@northwestern.edu
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