Int J Biochem Mol Biol 2013;4(1):1-26
Relationship between the proteasomal system and autophagy
Laboratory of Stress and Pathologies of the Cytoskeleton, Unit of Functional and Adaptive Biology (BFA) affiliated with CNRS (EAC4413),
University Paris Diderot-Paris 7, 75250 Paris Cedex 13, France
Received January 21, 2013; Accepted February 27, 2013; Epub March 31, 2013; Published April 15, 2013
Abstract: Two major pathways degrade most cellular proteins in eukaryotic cells: the ubiquitin–proteasome system (UPS), which usually
degrades the majority of proteins, and autophagy, primarily responsible for the degradation of most long-lived or aggregated proteins and
cellular organelles. Disruption of these processes can contribute to pathology of a variety of diseases. Further, both pathways are critical for the
maintenance of several aspects of cellular homeostasis, but, until recently, were thought to be largely distinct. Recent advances in this field,
however, now strongly suggest that their activities are carefully orchestrated through several interfacing elements that are presented and
discussed in this review. (IJBMB1301002).
Keywords: Proteasome, autophagy, ubiquitin, homeostasis
Address correspondence to: Dr. Alain Lilienbaum, University Paris 7 Denis Diderot CNRS EAC 4413, BFA - Unit of Functional and Adaptive
Biology, 4, rue Lagroua Weil-Hallé, 75250 Paris Cedex 13, France. Phone: 33 - 1 57 27 79 56; Fax: 33 - 1 57 27 79 53; E-mail: alain.