Int J Biochem Mol Biol 2013;4(2):102-107

Original Article
Identification of a FXIIIA variant in human neuroblastoma cell lines

Martina lannaccone, Gaia Giuberti, Giulia De Vivo, Michele Caraglia, Vittorio Gentile

Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, 80138 Naples, Italy

Received July 10, 2013; Accepted July 25, 2013; Epub July 29, 2013; Published August 15, 2013

Abstract: FXIII is a transglutaminase consisting of two catalytic (FXIIIA) and two non-catalytic subunits (FXIIIB) in plasma, where this enzyme is
responsible for stabilizing fibrin clots. Although possible functions of intracellular FXIIIA have been proposed, these remain to be established.
We show that a 40 kDa protein species of FXIIIA is present in the human neuroblastoma cell lines SH-SY5Y and LAN5. These data reveal the
presence of a new uncharacterised variant of FXIIIA, possibly due to an alternative splicing, in nervous cells. (IJBMB1307003).

Keywords: Transglutaminases, cellular factor XIII, post-translational modifications of proteins, CNS

Address correspondence to: Dr. Vittorio Gentile, Department of Biochemistry, Biophysics and General Pathology, Second University of Naples,
via Costantinopoli 16, 80138 Naples, Italy. Tel: 0039-81-5665870/7551; Fax: 0039-81-5665863; E-mail: vittorio.gentile@unina2.it
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